H2O

Overview of the growth coupled pathways towards this compound.

BiGG ID: h2o_c KEGG ID: C00001

Available chemistries

amn1_rev

R-aminated + akg_c → R + glu__L_c

Transaminase
amn3_rev

R-aminated3 + pyr_c → R + ala__L_c

Transaminase
amn4_rev

R-aminated4 + glx_c → R + gly_c

Transaminase
hdg4

R + trdrd_c → R-H2 + trdox_c

Reductases
mth1

R + amet_c → R-methylated + ahcys_c

Methyltransferases

Reaction routes

H2Ohdg4

Arsenate ion + Thioredoxin ⇄ Arsenite + Thioredoxin disulfide + H2O (1.20.4.4)
Thioredoxin: trdrd_c, Arsenate ion: aso4_c

Reversibility:
?

H2Ohdg4

Sarcosine + Orthophosphate + Thioredoxin ⇄ Acetyl phosphate + Methylamine + Thioredoxin disulfide + H2O (1.21.4.3)
Thioredoxin: trdrd_c, Sarcosine: sarcs_c, Orthophosphate: pi_c

Reversibility:
0.96±0.76

H2Ohdg4

Betaine + Orthophosphate + Thioredoxin ⇄ Acetyl phosphate + Trimethylamine + Thioredoxin disulfide + H2O (1.21.4.4)
Thioredoxin: trdrd_c, Betaine: glyb_c, Orthophosphate: pi_c

Reversibility:
?

H2Ohdg4

L-Methionine (S)-S-oxide + Thioredoxin ⇄ L-Methionine + Thioredoxin disulfide + H2O (1.8.4.11)
Thioredoxin: trdrd_c

Reversibility:
?

L-Methionine (S)-S-oxide

L-Methionine + Thioredoxin disulfide + H2O ⇄ L-Methionine (S)-S-oxide + Thioredoxin (1.8.4.11)
L-Methionine: met__L_c, Thioredoxin disulfide: trdox_c, H2O: h2o_c

Reversibility:
?

H2Omth1

9 Malonyl-CoA + 11 NADPH + 10 H+ + S-Adenosyl-L-methionine + Acyl-carrier protein ⇄ Dihydromonacolin L-[acyl-carrier protein] + 9 CoA + 9 CO2 + 11 NADP+ + S-Adenosyl-L-homocysteine + 6 H2O (2.3.1.161)
S-Adenosyl-L-methionine: amet_c, Malonyl-CoA: malcoa_c, NADPH: nadph_c, H+: h_c, Acyl-carrier protein: ACP_c

Reversibility:
?

H2Omth1

2 Malonyl-CoA + Acyl-carrier protein + 2 NADPH + 2 H+ + S-Adenosyl-L-methionine ⇄ (S)-2-Methylbutanoyl-[acp] + 2 CoA + 2 CO2 + 2 NADP+ + S-Adenosyl-L-homocysteine + H2O (2.3.1.244)
S-Adenosyl-L-methionine: amet_c, Malonyl-CoA: malcoa_c, Acyl-carrier protein: ACP_c, NADPH: nadph_c, H+: h_c

Reversibility:
?

H2Oamn1_rev

2-Oxoglutarate + Ammonia + NADPH + H+ ⇄ L-Glutamate + NADP+ + H2O (1.4.1.13)
2-Oxoglutarate: akg_c, Ammonia: nh4_c, NADPH: nadph_c, H+: h_c

Reversibility:
-2.63±0.06

H2Oamn1_rev

L-Kynurenine + 2-Oxoglutarate ⇄ 4-Hydroxy-2-quinolinecarboxylic acid + L-Glutamate + H2O (2.6.1.7)
2-Oxoglutarate: akg_c

Reversibility:
-24.39±1.13

L-Kynurenine

L-Formylkynurenine + H2O ⇄ Formate + L-Kynurenine (3.5.1.9)
H2O: h2o_c

Reversibility:
-14.33±1.51

L-Formylkynurenine

L-Tryptophan + O2 ⇄ L-Formylkynurenine (1.13.11.11)
L-Tryptophan: trp__L_c, O2: o2_c

Reversibility:
-87.40±1.77

H2Oamn1_rev

LL-2,6-Diaminoheptanedioate + 2-Oxoglutarate ⇄ 2,3,4,5-Tetrahydrodipicolinate + L-Glutamate + H2O (2.6.1.83)
2-Oxoglutarate: akg_c, LL-2,6-Diaminoheptanedioate: 26dap_LL_c

Reversibility:
-12.79±0.99

H2Oamn1_rev

2-Oxoglutarate + Ammonia + NADH + H+ ⇄ L-Glutamate + NAD+ + H2O (1.4.1.14)
2-Oxoglutarate: akg_c, Ammonia: nh4_c, NADH: nadh_c, H+: h_c

Reversibility:
-2.63±0.04

H2Oamn1_rev

2-Oxoglutarate + Ammonia + NADH + H+ ⇄ L-Glutamate + NAD+ + H2O (1.4.1.2)
2-Oxoglutarate: akg_c, Ammonia: nh4_c, NADH: nadh_c, H+: h_c

Reversibility:
-2.63±0.04

H2Oamn1_rev

2-Oxoglutarate + Ammonia + NADPH + H+ ⇄ L-Glutamate + NADP+ + H2O (1.4.1.4)
2-Oxoglutarate: akg_c, Ammonia: nh4_c, NADPH: nadph_c, H+: h_c

Reversibility:
-2.63±0.06

H2Oamn1_rev

2-Oxoglutarate + Ammonia + Hydrogen peroxide ⇄ L-Glutamate + O2 + H2O (1.4.3.11)
2-Oxoglutarate: akg_c, Ammonia: nh4_c, Hydrogen peroxide: h2o2_c

Reversibility:
18.26±0.68

H2Oamn3_rev

Pyruvate + Ammonia + NADH + H+ ⇄ L-Alanine + NAD+ + H2O (1.4.1.1)
Pyruvate: pyr_c, Ammonia: nh4_c, NADH: nadh_c, H+: h_c

Reversibility:
-2.66±0.09

H2Oamn4_rev

Glyoxylate + Ammonia + NADH + H+ ⇄ Glycine + H2O + NAD+ (1.4.1.10)
Glyoxylate: glx_c, Ammonia: nh4_c, NADH: nadh_c, H+: h_c

Reversibility:
-4.01±0.26

H2Oamn4_rev

L-Kynurenine + Glyoxylate ⇄ 4-Hydroxy-2-quinolinecarboxylic acid + Glycine + H2O (2.6.1.63)
Glyoxylate: glx_c

Reversibility:
-26.11±1.17

L-Kynurenine

L-Formylkynurenine + H2O ⇄ Formate + L-Kynurenine (3.5.1.9)
H2O: h2o_c

Reversibility:
-14.33±1.51

L-Formylkynurenine

L-Tryptophan + O2 ⇄ L-Formylkynurenine (1.13.11.11)
L-Tryptophan: trp__L_c, O2: o2_c

Reversibility:
-87.40±1.77

H2Oamn4_rev

3-Hydroxy-L-kynurenine + Glyoxylate ⇄ Xanthurenic acid + Glycine + H2O (2.6.1.63)
Glyoxylate: glx_c

Reversibility:
-26.16±1.17

3-Hydroxy-L-kynurenine

L-Kynurenine + O2 + NADPH + H+ ⇄ 3-Hydroxy-L-kynurenine + NADP+ + H2O (1.14.13.9)
O2: o2_c, NADPH: nadph_c, H+: h_c

Reversibility:
-68.23±0.61

L-Kynurenine

L-Formylkynurenine + H2O ⇄ Formate + L-Kynurenine (3.5.1.9)
H2O: h2o_c

Reversibility:
-14.33±1.51

L-Formylkynurenine

L-Tryptophan + O2 ⇄ L-Formylkynurenine (1.13.11.11)
L-Tryptophan: trp__L_c, O2: o2_c

Reversibility:
-87.40±1.77

H2Oamn4_rev

Glyoxylate + Ammonia + Hydrogen peroxide ⇄ Glycine + H2O + O2 (1.4.3.19)
Glyoxylate: glx_c, Ammonia: nh4_c, Hydrogen peroxide: h2o2_c

Reversibility:
16.88±0.72