Available chemistries
mth1
R + amet_c → R-methylated + ahcys_c
mth5
R + amet_c → met__L_c + dad_5_c + R-methylated5
Reaction routes
- CO2mth1
2 S-Adenosyl-L-methionine + Precorrin 6Y ⇄ 2 S-Adenosyl-L-homocysteine + Precorrin 8X + CO2 (2.1.1.132)
S-Adenosyl-L-methionine: amet_cReversibility:?- Precorrin 6Y
Precorrin 6X + NADPH + H+ ⇄ Precorrin 6Y + NADP+ (1.3.1.54)
NADPH: nadph_c, H+: h_cReversibility:?- Precorrin 6X
Precorrin 5 + S-Adenosyl-L-methionine + H2O ⇄ Precorrin 6X + Acetate + S-Adenosyl-L-homocysteine (2.1.1.152)
S-Adenosyl-L-methionine: amet_c, H2O: h2o_cReversibility:?- Precorrin 5
S-Adenosyl-L-methionine + Precorrin 4 ⇄ S-Adenosyl-L-homocysteine + Precorrin 5 (2.1.1.133)
S-Adenosyl-L-methionine: amet_cReversibility:?- Precorrin 4
S-Adenosyl-L-methionine + Precorrin 3B ⇄ S-Adenosyl-L-homocysteine + Precorrin 4 (2.1.1.131)
S-Adenosyl-L-methionine: amet_cReversibility:?- Precorrin 3B
Precorrin 3A + O2 + NADH + H+ ⇄ Precorrin 3B + NAD+ + H2O (1.14.13.83)
O2: o2_c, NADH: nadh_c, H+: h_cReversibility:?- Precorrin 3A
S-Adenosyl-L-methionine + Precorrin 2 ⇄ S-Adenosyl-L-homocysteine + Precorrin 3A + H+ (2.1.1.130)
S-Adenosyl-L-methionine: amet_c, Precorrin 2: dscl_cReversibility:?
- CO2mth1
9 Malonyl-CoA + 11 NADPH + 10 H+ + S-Adenosyl-L-methionine + Acyl-carrier protein ⇄ Dihydromonacolin L-[acyl-carrier protein] + 9 CoA + 9 CO2 + 11 NADP+ + S-Adenosyl-L-homocysteine + 6 H2O (2.3.1.161)
S-Adenosyl-L-methionine: amet_c, Malonyl-CoA: malcoa_c, NADPH: nadph_c, H+: h_c, Acyl-carrier protein: ACP_cReversibility:?
- CO2mth1
2 Malonyl-CoA + Acyl-carrier protein + 2 NADPH + 2 H+ + S-Adenosyl-L-methionine ⇄ (S)-2-Methylbutanoyl-[acp] + 2 CoA + 2 CO2 + 2 NADP+ + S-Adenosyl-L-homocysteine + H2O (2.3.1.244)
S-Adenosyl-L-methionine: amet_c, Malonyl-CoA: malcoa_c, Acyl-carrier protein: ACP_c, NADPH: nadph_c, H+: h_cReversibility:?
- CO2mth5
Coproporphyrinogen III + 2 S-Adenosyl-L-methionine ⇄ Protoporphyrinogen IX + 2 CO2 + 2 L-Methionine + 2 5'-Deoxyadenosine (1.3.98.3)
S-Adenosyl-L-methionine: amet_c, Coproporphyrinogen III: cpppg3_cReversibility:?
- CO2mth5
Fe-coproporphyrin III + 2 S-Adenosyl-L-methionine ⇄ Heme + 2 CO2 + 2 5'-Deoxyadenosine + 2 L-Methionine (1.3.98.6)
S-Adenosyl-L-methionine: amet_cReversibility:?