Available chemistries
amn1
R + glu__L_c → R-aminated + akg_c
Transaminase
amn3
R + ala__L_c → R-aminated3 + pyr_c
Transaminase
Reaction routes
- L-Lysineamn1
L-2-Aminoadipate 6-semialdehyde + L-Glutamate ⇄ L-Lysine + 2-Oxoglutarate (2.6.1.36)
L-Glutamate: glu__L_cReversibility:-0.07±0.48- L-2-Aminoadipate 6-semialdehyde
(S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + H2O ⇄ L-2-Aminoadipate 6-semialdehyde (1.2.1.31)
H2O: h2o_cReversibility:12.27±2.08- (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
L-Lysine + NAD+ ⇄ (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + NADH + H+ + Ammonia (1.4.1.18)
L-Lysine: lys__L_c, NAD+: nad_cReversibility:-2.22±0.93
- L-Lysineamn3
L-2-Aminoadipate 6-semialdehyde + L-Alanine ⇄ L-Lysine + Pyruvate (2.6.1.71)
L-Alanine: ala__L_cReversibility:-0.03±0.49- L-2-Aminoadipate 6-semialdehyde
(S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + H2O ⇄ L-2-Aminoadipate 6-semialdehyde (1.2.1.31)
H2O: h2o_cReversibility:12.27±2.08- (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
L-Lysine + NAD+ ⇄ (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + NADH + H+ + Ammonia (1.4.1.18)
L-Lysine: lys__L_c, NAD+: nad_cReversibility:-2.22±0.93