L-Methionine

Overview of the growth coupled pathways towards this compound.

BiGG ID: met__L_c KEGG ID: C00073

Available chemistries

amn4

R + gly_c → R-aminated4 + glx_c

Transaminase
hdg4

R + trdrd_c → R-H2 + trdox_c

Reductases

Reaction routes

L-Methioninehdg4

L-Methionine (S)-S-oxide + Thioredoxin ⇄ L-Methionine + Thioredoxin disulfide + H2O (1.8.4.11)
Thioredoxin: trdrd_c

Reversibility:
?

L-Methionine (S)-S-oxide

L-Methionine + Thioredoxin disulfide + H2O ⇄ L-Methionine (S)-S-oxide + Thioredoxin (1.8.4.11)
L-Methionine: met__L_c, Thioredoxin disulfide: trdox_c, H2O: h2o_c

Reversibility:
?

L-Methionineamn4

4-Methylthio-2-oxobutanoic acid + Glycine ⇄ L-Methionine + Glyoxylate (2.6.1.73)
Glycine: gly_c

Reversibility:
3.82±0.50

4-Methylthio-2-oxobutanoic acid

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one + O2 ⇄ 4-Methylthio-2-oxobutanoic acid + Formate (1.13.11.54)
O2: o2_c

Reversibility:
-103.77±0.67

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

2,3-Diketo-5-methylthiopentyl-1-phosphate + H2O ⇄ 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one + Orthophosphate (3.1.3.77)
H2O: h2o_c

Reversibility:
-8.84±0.34

2,3-Diketo-5-methylthiopentyl-1-phosphate

S-Methyl-5-thio-D-ribulose 1-phosphate ⇄ 2,3-Diketo-5-methylthiopentyl-1-phosphate + H2O (4.2.1.109)

Reversibility:
-16.55±0.50

S-Methyl-5-thio-D-ribulose 1-phosphate

S-Methyl-5-thio-D-ribose 1-phosphate ⇄ S-Methyl-5-thio-D-ribulose 1-phosphate (5.3.1.23)

Reversibility:
-4.08±1.00

S-Methyl-5-thio-D-ribose 1-phosphate

5'-Methylthioadenosine + Orthophosphate ⇄ Adenine + S-Methyl-5-thio-D-ribose 1-phosphate (2.4.2.28)
5'-Methylthioadenosine: 5mta_c, Orthophosphate: pi_c

Reversibility:
2.12±0.59

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O ⇄ 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one + Orthophosphate (3.1.3.77)
H2O: h2o_c

Reversibility:
-8.37±0.34

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

2,3-Diketo-5-methylthiopentyl-1-phosphate ⇄ 2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (3.1.3.77)

Reversibility:
-0.71±0.00

2,3-Diketo-5-methylthiopentyl-1-phosphate

S-Methyl-5-thio-D-ribulose 1-phosphate ⇄ 2,3-Diketo-5-methylthiopentyl-1-phosphate + H2O (4.2.1.109)

Reversibility:
-16.55±0.50

S-Methyl-5-thio-D-ribulose 1-phosphate

S-Methyl-5-thio-D-ribose 1-phosphate ⇄ S-Methyl-5-thio-D-ribulose 1-phosphate (5.3.1.23)

Reversibility:
-4.08±1.00

S-Methyl-5-thio-D-ribose 1-phosphate

5'-Methylthioadenosine + Orthophosphate ⇄ Adenine + S-Methyl-5-thio-D-ribose 1-phosphate (2.4.2.28)
5'-Methylthioadenosine: 5mta_c, Orthophosphate: pi_c

Reversibility:
2.12±0.59