L-2-Aminoadipate

2-Oxoadipate + L-Glutamate ⇄ L-2-Aminoadipate + 2-Oxoglutarate (2.6.1.39)
L-Glutamate: glu__L_c

2-Oxoadipate

Homoisocitrate + NAD⁺ ⇄ 2-Oxoadipate + CO₂ + NADH + H⁺ (1.1.1.87)
NAD⁺: nad_c

Reversibility:

-1.14±0.69

Homoisocitrate

(Z)-But-1-ene-1,2,4-tricarboxylate + H₂O ⇄ Homoisocitrate (4.2.1.36)
H₂O: h2o_c

Reversibility:

0.49±1.18

(Z)-But-1-ene-1,2,4-tricarboxylate

(R)-2-Hydroxybutane-1,2,4-tricarboxylate ⇄ (Z)-But-1-ene-1,2,4-tricarboxylate + H₂O (4.2.1.114)

Reversibility:

0.16±0.77

(R)-2-Hydroxybutane-1,2,4-tricarboxylate

Acetyl-CoA + H₂O + 2-Oxoglutarate ⇄ (R)-2-Hydroxybutane-1,2,4-tricarboxylate + CoA (2.3.3.14)
Acetyl-CoA: accoa_c, H₂O: h2o_c, 2-Oxoglutarate: akg_c

Reversibility:

-6.19±0.56