Neamine

Overview of the growth coupled pathways towards this compound.

Available chemistries

Reaction routes

Neamineamn1

6'-Dehydro-6'-oxoparomamine + L-Glutamate ⇄ Neamine + 2-Oxoglutarate (2.6.1.93)
L-Glutamate: glu__L_c

Reversibility:
-1.39±0.40

6'-Dehydro-6'-oxoparomamine

Paromamine + O2 ⇄ 6'-Dehydro-6'-oxoparomamine + Hydrogen peroxide (1.1.3.43)
O2: o2_c

Reversibility:
-22.56±0.85

Paromamine

2'-N-Acetylparomamine + H2O ⇄ Paromamine + Acetate (3.5.1.112)
H2O: h2o_c

Reversibility:
-7.99±0.49

2'-N-Acetylparomamine

UDP-N-acetyl-alpha-D-glucosamine + 2-Deoxystreptamine ⇄ UDP + 2'-N-Acetylparomamine (2.4.1.283)
UDP-N-acetyl-alpha-D-glucosamine: uacgam_c

Reversibility:
-3.03±0.71

2-Deoxystreptamine

3-Amino-2,3-dideoxy-scyllo-inosose + L-Glutamine ⇄ 2-Deoxystreptamine + 2-Oxoglutaramate (2.6.1.101)
L-Glutamine: gln__L_c

Reversibility:
2.99±0.66

3-Amino-2,3-dideoxy-scyllo-inosose

2-Deoxy-scyllo-inosamine + S-Adenosyl-L-methionine ⇄ 3-Amino-2,3-dideoxy-scyllo-inosose + L-Methionine + 5'-Deoxyadenosine (1.1.99.38)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

2-Deoxy-scyllo-inosamine

2-Deoxy-scyllo-inosose + L-Glutamine ⇄ 2-Deoxy-scyllo-inosamine + 2-Oxoglutaramate (2.6.1.100)
L-Glutamine: gln__L_c

Reversibility:
3.51±0.66

2-Deoxy-scyllo-inosose

D-Glucose 6-phosphate ⇄ 2-Deoxy-scyllo-inosose + Orthophosphate (4.2.3.124)
D-Glucose 6-phosphate: g6p_c

Reversibility:
-41.08±1.87