5'-Deoxyadenosine

Overview of the growth coupled pathways towards this compound.

BiGG ID: dad_5_c KEGG ID: C05198

Available chemistries

mth5

R + amet_c → met__L_c + dad_5_c + R-methylated5

Methyltransferases

Reaction routes

5'-Deoxyadenosinemth5

2-Deoxy-scyllo-inosamine + S-Adenosyl-L-methionine ⇄ 3-Amino-2,3-dideoxy-scyllo-inosose + L-Methionine + 5'-Deoxyadenosine (1.1.99.38)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

2-Deoxy-scyllo-inosamine

2-Deoxy-scyllo-inosose + L-Glutamine ⇄ 2-Deoxy-scyllo-inosamine + 2-Oxoglutaramate (2.6.1.100)
L-Glutamine: gln__L_c

Reversibility:
3.51±0.66

2-Deoxy-scyllo-inosose

D-Glucose 6-phosphate ⇄ 2-Deoxy-scyllo-inosose + Orthophosphate (4.2.3.124)
D-Glucose 6-phosphate: g6p_c

Reversibility:
-41.08±1.87

5'-Deoxyadenosinemth5

Magnesium protoporphyrin monomethyl ester + S-Adenosyl-L-methionine + H2O ⇄ 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + 5'-Deoxyadenosine + L-Methionine (1.21.98.3)
S-Adenosyl-L-methionine: amet_c, H2O: h2o_c

Reversibility:
?

Magnesium protoporphyrin monomethyl ester

S-Adenosyl-L-methionine + Magnesium protoporphyrin ⇄ S-Adenosyl-L-homocysteine + Magnesium protoporphyrin monomethyl ester (2.1.1.11)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

Magnesium protoporphyrin

ATP + Protoporphyrin + Magnesium cation + H2O ⇄ ADP + Orthophosphate + Magnesium protoporphyrin + 2 H+ (6.6.1.1)
ATP: atp_c, Protoporphyrin: ppp9_c, Magnesium cation: mg2_c, H2O: h2o_c

Reversibility:
?

5'-Deoxyadenosinemth5

13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + S-Adenosyl-L-methionine ⇄ 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester + 5'-Deoxyadenosine + L-Methionine (1.21.98.3)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester

Magnesium protoporphyrin monomethyl ester + NADPH + H+ + O2 ⇄ 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O (1.14.13.81)
NADPH: nadph_c, H+: h_c, O2: o2_c

Reversibility:
?

Magnesium protoporphyrin monomethyl ester

S-Adenosyl-L-methionine + Magnesium protoporphyrin ⇄ S-Adenosyl-L-homocysteine + Magnesium protoporphyrin monomethyl ester (2.1.1.11)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

Magnesium protoporphyrin

ATP + Protoporphyrin + Magnesium cation + H2O ⇄ ADP + Orthophosphate + Magnesium protoporphyrin + 2 H+ (6.6.1.1)
ATP: atp_c, Protoporphyrin: ppp9_c, Magnesium cation: mg2_c, H2O: h2o_c

Reversibility:
?

5'-Deoxyadenosinemth5

13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester + S-Adenosyl-L-methionine ⇄ Divinylprotochlorophyllide + 5'-Deoxyadenosine + L-Methionine (1.21.98.3)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester

13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 ⇄ 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O (1.14.13.81)
NADPH: nadph_c, H+: h_c, O2: o2_c

Reversibility:
?

13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester

Magnesium protoporphyrin monomethyl ester + NADPH + H+ + O2 ⇄ 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O (1.14.13.81)
NADPH: nadph_c, H+: h_c, O2: o2_c

Reversibility:
?

Magnesium protoporphyrin monomethyl ester

S-Adenosyl-L-methionine + Magnesium protoporphyrin ⇄ S-Adenosyl-L-homocysteine + Magnesium protoporphyrin monomethyl ester (2.1.1.11)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

Magnesium protoporphyrin

ATP + Protoporphyrin + Magnesium cation + H2O ⇄ ADP + Orthophosphate + Magnesium protoporphyrin + 2 H+ (6.6.1.1)
ATP: atp_c, Protoporphyrin: ppp9_c, Magnesium cation: mg2_c, H2O: h2o_c

Reversibility:
?

5'-Deoxyadenosinemth5

Coproporphyrinogen III + 2 S-Adenosyl-L-methionine ⇄ Protoporphyrinogen IX + 2 CO2 + 2 L-Methionine + 2 5'-Deoxyadenosine (1.3.98.3)
S-Adenosyl-L-methionine: amet_c, Coproporphyrinogen III: cpppg3_c

Reversibility:
?

5'-Deoxyadenosinemth5

Fe-coproporphyrin III + 2 S-Adenosyl-L-methionine ⇄ Heme + 2 CO2 + 2 5'-Deoxyadenosine + 2 L-Methionine (1.3.98.6)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

Fe-coproporphyrin III

Heme + 2 CO2 + 4 H2O ⇄ Fe-coproporphyrin III + 2 Hydrogen peroxide (1.3.98.5)
Heme: pheme_c, CO2: co2_c, H2O: h2o_c

Reversibility:
?

Fe-coproporphyrin III

Harderoheme III + CO2 + 2 H2O ⇄ Fe-coproporphyrin III + Hydrogen peroxide (1.3.98.5)
CO2: co2_c, H2O: h2o_c

Reversibility:
?

Harderoheme III

Heme + CO2 + 2 H2O ⇄ Harderoheme III + Hydrogen peroxide (1.3.98.5)
Heme: pheme_c, CO2: co2_c, H2O: h2o_c

Reversibility:
?

5'-Deoxyadenosinemth5

5-Amino-6-(1-D-ribitylamino)uracil + L-Tyrosine + S-Adenosyl-L-methionine ⇄ 5-Amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + Iminoglycine + L-Methionine + 5'-Deoxyadenosine (2.5.1.147)
S-Adenosyl-L-methionine: amet_c, 5-Amino-6-(1-D-ribitylamino)uracil: 4r5au_c, L-Tyrosine: tyr__L_c

Reversibility:
?

5'-Deoxyadenosinemth5

Aminoimidazole ribotide + S-Adenosyl-L-methionine ⇄ 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-Deoxyadenosine + L-Methionine + Formate + CO (4.1.99.17)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

Aminoimidazole ribotide

1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate ⇄ Aminoimidazole ribotide + CO2 (4.1.1.21)
1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate: 5aizc_c

Reversibility:
-2.20±1.15

5'-Deoxyadenosinemth5

5-Amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-Adenosyl-L-methionine ⇄ 7,8-Didemethyl-8-hydroxy-5-deazariboflavin + Ammonia + L-Methionine + 5'-Deoxyadenosine (4.3.1.32)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

5-Amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil

5-Amino-6-(1-D-ribitylamino)uracil + L-Tyrosine + S-Adenosyl-L-methionine ⇄ 5-Amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + Iminoglycine + L-Methionine + 5'-Deoxyadenosine (2.5.1.147)
5-Amino-6-(1-D-ribitylamino)uracil: 4r5au_c, L-Tyrosine: tyr__L_c, S-Adenosyl-L-methionine: amet_c

Reversibility:
?