4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate

Overview of the growth coupled pathways towards this compound.

KEGG ID: C05645

Available chemistries

amn4_rev

R-aminated4 + glx_c → R + gly_c

Transaminase

Reaction routes

4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoateamn4_rev

3-Hydroxy-L-kynurenine + Glyoxylate ⇄ 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate + Glycine (2.6.1.63)
Glyoxylate: glx_c

Reversibility:
-3.31±0.48

3-Hydroxy-L-kynurenine

L-Kynurenine + O2 + NADPH + H+ ⇄ 3-Hydroxy-L-kynurenine + NADP+ + H2O (1.14.13.9)
O2: o2_c, NADPH: nadph_c, H+: h_c

Reversibility:
-68.23±0.61

L-Kynurenine

L-Formylkynurenine + H2O ⇄ Formate + L-Kynurenine (3.5.1.9)
H2O: h2o_c

Reversibility:
-14.33±1.51

L-Formylkynurenine

L-Tryptophan + O2 ⇄ L-Formylkynurenine (1.13.11.11)
L-Tryptophan: trp__L_c, O2: o2_c

Reversibility:
-87.40±1.77