3,22-Dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene

Overview of the growth coupled pathways towards this compound.

KEGG ID: C20412

Available chemistries

mth1

R + amet_c → R-methylated + ahcys_c

Methyltransferases

Reaction routes

3,22-Dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualenemth1

2 S-Adenosyl-L-methionine + Squalene ⇄ 2 S-Adenosyl-L-homocysteine + 3,22-Dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene (2.1.1.262)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

Squalene

Presqualene diphosphate + NADPH + H+ ⇄ Diphosphate + Squalene + NADP+ (1.3.1.96)
NADPH: nadph_c, H+: h_c

Reversibility:
-4.80±1.25

Presqualene diphosphate

2 trans,trans-Farnesyl diphosphate ⇄ Diphosphate + Presqualene diphosphate (2.5.1.21)
trans,trans-Farnesyl diphosphate: frdp_c

Reversibility:
-32.10±1.57

3,22-Dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualenemth1

S-Adenosyl-L-methionine + 3-Methyl-1,2-didehydro-2,3-dihydrosqualene ⇄ S-Adenosyl-L-homocysteine + 3,22-Dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene (2.1.1.262)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

3-Methyl-1,2-didehydro-2,3-dihydrosqualene

S-Adenosyl-L-methionine + Squalene ⇄ S-Adenosyl-L-homocysteine + 3-Methyl-1,2-didehydro-2,3-dihydrosqualene (2.1.1.262)
S-Adenosyl-L-methionine: amet_c

Reversibility:
?

Squalene

Presqualene diphosphate + NADPH + H+ ⇄ Diphosphate + Squalene + NADP+ (1.3.1.96)
NADPH: nadph_c, H+: h_c

Reversibility:
-4.80±1.25

Presqualene diphosphate

2 trans,trans-Farnesyl diphosphate ⇄ Diphosphate + Presqualene diphosphate (2.5.1.21)
trans,trans-Farnesyl diphosphate: frdp_c

Reversibility:
-32.10±1.57